Indocyanine Green is a cyanine dye with a peak absorption of about 800 nm in the near-infrared spectrum. It binds firmly to plasma proteins, is confined to the vascular system, and is removed from circulation by the liver into bile. Initially developed during World War II for photography, it was later adopted for medical uses acquiring FDA approval in 1959. Its optical effects allow for deep-tissue imaging, specifically in areas like the retina and choroid.
CAS No.: 3599-32-4
Synonyms: Wofaverdin; Cardiogreen; Fox Green; Ujoviridin; HWD Indocyanine Green; Cardio-Green; Spy agent green; Verde indocianina; Vertd’indocyanine.
| Physical Properties | |
| Chemical formula | C43H47N2NaO6S2 |
| IUPAC Name | sodium;4-[(2Z)-2-[(2E,4E,6E)-7-[1,1-dimethyl-3-(4-sulfonatobutyl)benzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonate |
| Molecular weight | 775.0 g/mol |
| Solubility | Water, Methanol, Ethanol, DMSO, and dimethyl formamide |
| Density | 1.2 g/cm³ |
| Chemical Properties | |
| Color | Dark Green |
| State | Powder |
| Melting point | 218 °C |
| LogP | 6.05 |
| λmax | 800 nm |
| Pictograms : |
|
| Hazard Statements : | H315: Causes skin irritation |
| Precautionary statements : | P280: Wear protective gloves/eye protection |
Indocyanine Green is a cyanine dye with a peak absorption of about 800 nm in the near-infrared spectrum. It binds firmly to plasma proteins, is confined to the vascular system, and is removed from circulation by the liver into bile. Initially developed during World War II for photography, it was later adopted for medical uses acquiring FDA approval in 1959. Its optical effects allow for deep-tissue imaging, specifically in areas like the retina and choroid.
CAS No.: 3599-32-4
Synonyms: Wofaverdin; Cardiogreen; Fox Green; Ujoviridin; HWD Indocyanine Green; Cardio-Green; Spy agent green; Verde indocianina; Vertd’indocyanine.
| Physical Properties | |
| Chemical formula | C43H47N2NaO6S2 |
| IUPAC Name | sodium;4-[(2Z)-2-[(2E,4E,6E)-7-[1,1-dimethyl-3-(4-sulfonatobutyl)benzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonate |
| Molecular weight | 775.0 g/mol |
| Solubility | Water, Methanol, Ethanol, DMSO, and dimethyl formamide |
| Density | 1.2 g/cm³ |
| Chemical Properties | |
| Color | Dark Green |
| State | Powder |
| Melting point | 218 °C |
| LogP | 6.05 |
| λmax | 800 nm |
| Pictograms : |
|
| Hazard Statements : | H315: Causes skin irritation |
| Precautionary statements : | P280: Wear protective gloves/eye protection |
Indocyanine Green is a cyanine dye used generally in medical diagnostics. It has strong absorption and fluorescence properties in the near-infrared region.
Indocyanine Green absorbs near-infrared light and fluoresces, allowing for imaging of blood flow and tissue perfusion. It binds to plasma proteins, remaining in the vascular system for 30 minutes before being excreted by the liver.
It has a half-life of about 150-180 seconds in the body. It is typically cleared from the circulation within a few minutes and is excreted by the liver.
It is utilized in endometriosis surgery to enhance visualization of endometrial lesions and vascular structures. It highlights blood vessels and tissue abnormalities using near-infrared imaging, improving visualization and precision during the procedure.
Yes, Indocyanine Green contains iodine, which enhances its visibility in medical imaging.
