Acriflavine hydrochloride (Acriflavinium chloride hydrochloride) is a fluorescent acridine dye belonging to the class of acridines. It is widely used in various industries, like healthcare, veterinary medicine, and research for the making of antiseptics and disinfectants, cellular DNA, and protein analysis, to check the crypt structure in mucosa in living mice. This compound is available in multiple forms, such as Acriflavine solution and Acriflavine powder, making it versatile for different applications. It appears as a yellow to orange crystalline powder and is soluble in water, forming a yellow solution. Acriflavine HCl is known for its ability to form salts with acids due to its basic nature.
CAS No.:8063-24-9
Synonyms: 3,6-Diamino-10-methylacridinium chloride hydrochloride; Euflavin; Trypaflavine; Neutroflavine; Gonacrine.
Resources: Biological Stains | Classification, Examples & Uses
| Physical Properties | |
| Chemical formula | C27H28Cl4N6 |
| IUPAC Name | acridine-3,6-diamine;10-methylacridin-10-ium-3,6-diamine;chloride;trihydrochloride |
| Molecular weight | 578.4 g/mol |
| Solubility | Water, Methanol & dimethyl sulfoxide. |
| Density | 1.14 g/cm³ |
| Chemical Properties | |
| Color | Brownish-orange |
| State | Powder |
| Melting point | 258 °C |
| λmax | 460 ± 4 nm |
| pKa | 2.35 |
| LogP | -2.8 |
Confocal Laser Endomicroscopy: In living mice, Acriflavine Hydrochloride is used in confocal laser endomicroscopy to examine the crypt structure in mucosa. This application helps in the high-resolution imaging of tissue structures.
Neurospora Strain Selection: It has been employed in the selection of Neurospora strains by testing acriflavine resistance, aiding genetic research, and microbial studies.
Fluorescent Microscopy: Acriflavine Hydrochloride is a fluorescent dye commonly used as a topical contrast agent in microscopy. It primarily stains nuclei, improving visibility in tissue imaging.
| Pictograms : |    |
| Hazard Statements : | H302: Harmful if swallowed. H318: Causes serious eye damage. H411: Toxic to aquatic life with long-lasting effects. |
| Precautionary statements : | P264: Wash skin thoroughly after handling. P273: Avoid release to the environment. P280: Wear eye protection/ face protection. P301 + P312: IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present, and easy to do. Continue rinsing. P391: Collect spillage. |
Acriflavine hydrochloride (Acriflavinium chloride hydrochloride) is a fluorescent acridine dye belonging to the class of acridines. It is widely used in various industries, like healthcare, veterinary medicine, and research for the making of antiseptics and disinfectants, cellular DNA, and protein analysis, to check the crypt structure in mucosa in living mice. This compound is available in multiple forms, such as Acriflavine solution and Acriflavine powder, making it versatile for different applications. It appears as a yellow to orange crystalline powder and is soluble in water, forming a yellow solution. Acriflavine HCl is known for its ability to form salts with acids due to its basic nature.
CAS No.:8063-24-9
Synonyms: 3,6-Diamino-10-methylacridinium chloride hydrochloride; Euflavin; Trypaflavine; Neutroflavine; Gonacrine.
Resources: Biological Stains | Classification, Examples & Uses
| Physical Properties | |
| Chemical formula | C27H28Cl4N6 |
| IUPAC Name | acridine-3,6-diamine;10-methylacridin-10-ium-3,6-diamine;chloride;trihydrochloride |
| Molecular weight | 578.4 g/mol |
| Solubility | Water, Methanol & dimethyl sulfoxide. |
| Density | 1.14 g/cm³ |
| Chemical Properties | |
| Color | Brownish-orange |
| State | Powder |
| Melting point | 258 °C |
| λmax | 460 ± 4 nm |
| pKa | 2.35 |
| LogP | -2.8 |
Confocal Laser Endomicroscopy: In living mice, Acriflavine Hydrochloride is used in confocal laser endomicroscopy to examine the crypt structure in mucosa. This application helps in the high-resolution imaging of tissue structures.
Neurospora Strain Selection: It has been employed in the selection of Neurospora strains by testing acriflavine resistance, aiding genetic research, and microbial studies.
Fluorescent Microscopy: Acriflavine Hydrochloride is a fluorescent dye commonly used as a topical contrast agent in microscopy. It primarily stains nuclei, improving visibility in tissue imaging.
| Pictograms : | |
| Hazard Statements : | H302: Harmful if swallowed. H318: Causes serious eye damage. H411: Toxic to aquatic life with long-lasting effects. |
| Precautionary statements : | P264: Wash skin thoroughly after handling. P273: Avoid release to the environment. P280: Wear eye protection/ face protection. P301 + P312: IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present, and easy to do. Continue rinsing. P391: Collect spillage. |
Acriflavine HCl is a hydrochloride salt of acriflavine, a compound used as an antiseptic and fluorescent dye in scientific research.
Acriflavine powder is an effective treatment for fish, addressing bacterial, fungal, and protozoal infections such as Columnaris, fin rot, Saprolegnia, and Ich.
It functions as a fluorescent dye that stains cell nuclei and DNA, making it valuable in microscopy and molecular biology studies.
Potential side effects of acriflavine HCl include skin irritation, allergic reactions, and staining of skin or tissues. It may also cause nausea if ingested.
It is effective in treating bacterial, fungal, and protozoal infections in fish, disinfecting fish eggs, and can be applied in bath treatments or directly.
Acriflavine HCl is used in veterinary medicine to treat wounds, infections, and bacterial diseases in animals. It is also applied in aquaculture to combat fungal, bacterial, and protozoal infections in fish.
