Denatonium Benzoate usually known as denatonium, is the most bitter chemical compound analyzed, with very low bitterness thresholds (0.05 ppm). Discovered in 1958, it is a quaternary ammonium cation usually detected as a salt, such as benzoate or saccharinate. It is extracted from the quaternization of lidocaine with benzyl chloride or similar reagents. Denatonium is colorless, and odorless, and is utilized mostly as a frigid agent to forbid ingestion of hazardous substances.
CAS No.: 3734-33-6
Synonyms: 2-Benzoate de denatonium; Bittering agent; Denaturant or denaturing agent; Lidocaine benzyl benzoate; Benzyldiethyl[(2,6-xylylcarbamoyl)methyl] ammonium benzoate; Benzenemethanaminium,N-(2-((2,6-dimethylphenyl) amino) -2-oxoethyl)-N, N-diethyl-,benzoate; Benzyldiethyl[(2,6-dimethylphenylcarbamoyl)methyl]ammonium benzoate.
| Physical Properties | |
| Chemical formula | C₂₈H₃₄N₂O₃ |
| IUPAC Name | benzyl({[(2,6-dimethylphenyl)carbamoyl]methyl})diethylazanium benzoate |
| Molecular weight | 446.58 g/mol |
| Solubility | Water, methanol, ethanol, isopropyl alcohol, and acetonitrile |
| Density | 1.1256 g/cm³ at 25°C |
| pH | between 6.5 and 7.5 |
| Flash point | 100℃ |
| Chemical Properties | |
| Color | White |
| State | Crystalline Powder or granules |
| Melting point | 163 to 170 °C |
| Bitterness thresholds | 0.05 ppm |
| Refractive index | 1.5800 (estimate) |
| Pictograms : |  |
| Hazard Statements : | H302: Harmful if swallowed |
| Precautionary statements : | P261: Avoid breathing dust/fume/gas/mist/vapors/spray P264: Wash thoroughly after handling P310: Immediately call a POISON CENTER/doctor P321: Specific treatment (see on this label) P403+P233: Store in a well-ventilated place. Keep the container tightly closed P405: Store locked up |
Denatonium Benzoate usually known as denatonium, is the most bitter chemical compound analyzed, with very low bitterness thresholds (0.05 ppm). Discovered in 1958, it is a quaternary ammonium cation usually detected as a salt, such as benzoate or saccharinate. It is extracted from the quaternization of lidocaine with benzyl chloride or similar reagents. Denatonium is colorless, and odorless, and is utilized mostly as a frigid agent to forbid ingestion of hazardous substances.
CAS No.: 3734-33-6
Synonyms: 2-Benzoate de denatonium; Bittering agent; Denaturant or denaturing agent; Lidocaine benzyl benzoate; Benzyldiethyl[(2,6-xylylcarbamoyl)methyl] ammonium benzoate; Benzenemethanaminium,N-(2-((2,6-dimethylphenyl) amino) -2-oxoethyl)-N, N-diethyl-,benzoate; Benzyldiethyl[(2,6-dimethylphenylcarbamoyl)methyl]ammonium benzoate.
| Physical Properties | |
| Chemical formula | C₂₈H₃₄N₂O₃ |
| IUPAC Name | benzyl({[(2,6-dimethylphenyl)carbamoyl]methyl})diethylazanium benzoate |
| Molecular weight | 446.58 g/mol |
| Solubility | Water, methanol, ethanol, isopropyl alcohol, and acetonitrile |
| Density | 1.1256 g/cm³ at 25°C |
| pH | between 6.5 and 7.5 |
| Flash point | 100℃ |
| Chemical Properties | |
| Color | White |
| State | Crystalline Powder or granules |
| Melting point | 163 to 170 °C |
| Bitterness thresholds | 0.05 ppm |
| Refractive index | 1.5800 (estimate) |
| Pictograms : | |
| Hazard Statements : | H302: Harmful if swallowed |
| Precautionary statements : | P261: Avoid breathing dust/fume/gas/mist/vapors/spray P264: Wash thoroughly after handling P310: Immediately call a POISON CENTER/doctor P321: Specific treatment (see on this label) P403+P233: Store in a well-ventilated place. Keep the container tightly closed P405: Store locked up |
Inhaling Denatonium Benzoate can be irritating and should be avoided.
Denatonium Benzoate has low volatility and does not readily evaporate under normal conditions.
Denatonium benzoate is a highly bitter compound used as a deterrent in various products to prevent accidental ingestion or misuse. It is known for being one of the most bitter substances.
Hydrogen peroxide and activated carbon were most effective in removing denatonium benzoate in the solution phase.
Apply liberally on nails and skin and allow the solution to dry for 10 minutes.
